Symatese - Nevelia®

Nevelia Bi-Layer Matrix


  1. De Angelis B. et al, Long-term follow-up comparison of two different bi-layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings Int Wound J 1–12 (2018)
  2. Montanaro, M. et al, Macrophage Activation and M2 Polarization in Wound Bed of Diabetic Patients Treated by Dermal / Epidermal Substitute Nevelia.Int. J. Low. Extrem. Wounds 1–7 (2020)
  3. Yiğitbaş, H. et al, Our experience with dermal substitute Nevelia® in the treatment of severely burned patients. Turkish J. Trauma Emerg. Surg. 25 (5): 520–526; (2019).
  4. De Angelis B. et al, Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute. J. Clin. Med. 8, 525 (2019).
  5. Gurbuz, K., Demir, M. & Das, K. The use of dermal substitute in deep burns of functional/mobile anatomic areas at acute phase after early excision and subsequent skin autografting: Dermal substitute prevents functional limitations J. Burn Care Res. 41, 1079–1083 (2020).
  6. Uccioli, L., Meloni, M., Izzo, V. & Giurato, L. Use of Nevelia Dermal-Epidermal Regenerative Template in the Management of Ischemic Diabetic Foot Postsurgical Wounds. Int. J. Low. Extrem. Wounds 19, 282–288 (2020).
  7. Alet, J. M. et al Collagen regeneration template in the management of full-thickness wounds: A prospective multicentre study.J. Wound Care 28, S22–S30 (2019).
  8. Cottone, G. et al. Comparison of Efficacy among Three Dermal Substitutes in the Management of Critical Lower-Limb Wounds: The Largest Biases-Reduced Single-Center Retrospective Cohort Study in Literature. Med. 57, 1–10 (2021).Med. 57, 1–10 (2021).
  9. Nicoletti, G. et al. Versatile use of dermal substitutes : A retrospective survey of 127 consecutive cases. Indian J Plast Surg 51, 46–53 (2018). Indian J Plast Surg 51, 46–53 (2018).
  10. Rekatsinas, S., Fotiou, A. & Kassos, C. A case report of reconstruction of the great Toe with a homodigital island flap. Plast Reconstr Surg Glob Open 9, 1–10 (2021). Plast Reconstr Surg Glob Open 9, 1–10 (2021).
  11. Jacome-Santos, H. et al.Acellular dermal matrix used after large surgical resection in ameloblastoma with buccal mucosa extension- a case report. Res. Soc. Dev. 10, 1–10 (2021).Res. Soc. Dev. 10, 1–10 (2021).
  12. Lipový, B. et al. Trichoderma longibrachiatum and Aspergillus fischeri Infection as a Cause of Skin Graft Failure in a Patient with Critical Burns after Liver Transplantation. J. Fungi 7, 487 (2021).
  13. Swartzwelter, B. J. et al. Interaction between macrophages and nanoparticles: In vitro 3d cultures for the realistic assessment of inflammatory activation and modulation of innate memory. Nanomaterials 11, 1–13 (2021).
  14. Tchero, al Failure rates of artificial dermis products in treatment of diabetic foot ulcer : A systematic review and network meta-analisys. Wound Repair Regen. 25, 691–696 (2017).
  15. Rehak, L. et al. The Immune-Centric Revolution in the Diabetic Foot : Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration . A Narrative Review. J. Clin. Med. 11, 889 (2022).
  16. Urciuolo, F et al Bioengineered skin substitutes: The role of extracellular matrix and vascularization in the healing of deep wounds. J. Clin. Med. 8, (2019).
  17. David Solarte et al Tissue for wound healing: towards closing the gap between scaffold design and effective extracellular matrix remodelling Front. Bioeng. Biotechnol. 10, (2022).

Abstracts & Poster

  1. Uccioli L. Use of a new dermal substitute in DFU – Journee Cicatrization – SESSION UPDATES IN WOUND TECHNOLOGIES (UWT) Paris 22-23 March 2018
  2. Casoli V et al Prospective evaluation of NEVELIA® in terms of safety and efficacy for third-degree burns treatment and reconstructive surgery – University Hospital of Bordeaux: electronic poster presentation – EWMA 2017 – Amsterdam 3-5 May 2017
  3. Brambilla R. et al  New collagen dermal substitute*: our experience – Poster WUWHS Florence 25-29 September 2016
  4. Barbara De Angelis et al Use of a new dermal substitute in difficult ulcers PO 219-ID460 Journal of Wound care WUWHS Florence  2016
  5. Barbara De Angelis et al Trattamento con sostituto dermico innovativo dei monconi da amputazione complicati- Poster 75- XV Congresso AIUC Napoli October  2019
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